THE biggest-ever trawl of the human genome for cancer-causing DNA errors has netted more than 80 tiny mutations, a finding that could help people at high risk, researchers say.
The results, which double the number of known genetic alterations linked to breast, ovarian and prostate cancer, were unveiled in a dozen scientific papers published in journals in Europe and the United States.
The three hormone-related cancers are diagnosed in over 2.5 million people every year and kill one in three patients, said a Nature press statement.
Teams from more than 100 research institutes in Europe, Asia, Australia and the United States said the work should in the future help doctors to calculate an individual's cancer risk long before any symptoms emerge.
People with high-susceptibility mutations could be counselled against lifestyle choices that further increase their risk, given regular screening and drug treatment, or even preventative surgery.
"We have examined 200,000 areas of the genome in 250,000 individuals. There is no (other) study of cancer of this size," Per Hall, coordinator of the Collaborative Oncological Gene-environment Study (COGS), told AFP of the research.
The studies compared the DNA of more than 100,000 patients with breast, ovarian and prostate cancer to that of an equal number of healthy individuals. Most were of European ancestry.
Everyone has inherited alterations in their DNA, but whether these mutations are dangerous or not is determined by where on the code they lie.
And carrying a mutation does not necessarily mean a person will develop cancer, a disease that may have multiple causes.
The researchers said further study is needed to allow scientists to translate these DNA telltales into tests for predicting cancer risk. A more distant goal is using the knowledge for better treatments.
The findings were published in Nature Genetics and Nature Communications, PLOS Genetics, the American Journal of Human Genetics and Human Molecular Genetics.
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